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すべて | Journal
Cortical gene expression architecture links healthy neurodevelopment to the imaging, transcriptomics and genetics of autism and schizophrenia
Gene expression in the human cortex is shown to involve three general components, which reflect metabolic and immune programs of healthy development, and link case–control imaging and transcriptomics to genetic risk for autism and schizophrenia.
Richard Dear
Konrad Wagstyl
Petra E. Vértes
ArticleOpen Access22 Apr 2024
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer’s disease model mouse brain
Neuroinflammation and microglia significantly contribute to Alzheimer’s disease pathology, depending on their activation state. We found that TREM2-expressing microglia are a heterogenous population spanning activated to senescent cells.
Noa Rachmian
Sedi Medina
Michal Schwartz
Article18 Apr 2024
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration
Using human
Current Issue Table of Contents: 24 Apr 2024 Volume 44, Issue 17
Pictured is a confocal microscopy image of a mouse brain slice showing dense cholinergic innervation in the basolateral amygdala (BLA), a limbic brain structure that is critical in emotional processes. Using channelrhodopsin (tagged with EYFP, green) in axonal fibers containing vesicular acetylcholine transporter (magenta), Joshua Bratsch-Prince et al. released endogenous acetylcholine in BLA circuits to explore how this uniquely strong cholinergic projection impacted network activity and the cell-type specific mechanism underlying it. The blue is a DAPI stain showing BLA cells. For more information on how acetylcholine modulates BLA circuits, see the article by Bratsch-Prince et al. Cover image: Grace Jones.
April 24, 2024
Review
Re-examining the Mysterious Role of the Cerebellum in Pain
April 24, 2024
Research Articles, Systems/Circuits
Neuronal Modeling of Cross-Sensory Visual Evoked Magnetoencephalography Responses in
The language network as a natural kind within the broader landscape of the human brain
Evelina Fedorenko
Anna A. Ivanova
Tamar I. Regev
Review Article 12 April 2024
The language network as a natural kind within the broader landscape of the human brain
Many brain areas support complex language processing behaviours. In this Review, Fedorenko et al. disentangle the ‘core’ language system as functionally distinct from the perceptual and motor brain areas and knowledge and reasoning systems it closely interacts with during language comprehension and production.
Evelina Fedorenko
Anna A. Ivanova
Tamar I. Regev
Review Article12 Apr 2024
Key genes and convergent pathogenic mechanisms in Parkinson disease
Parkinson disease (PD) has been linked to dysfunction in a number of key intracellular signalling pathways that contribute to disease pathology. Coukos and Krainc describe the physiological functions of a selection of PD-linked proteins and their convergent effects on mitochondrial, lysosomal
How to freeze a memory: putting worms on ice stops them forgetting
The model organism Caenorhabditis elegans is quick to forget a notable odour — unless it is chilled or given lithium.
Australia’s Great Barrier Reef is ‘transforming’ from repeated coral bleaching
The coral reef is currently experiencing its worst mass bleaching event on record — warming waters brought on by climate change are to blame.
Bianca Nogrady
News19 Apr 2024
Will AI accelerate or delay the race to net-zero emissions?
As artificial intelligence transforms the global economy, researchers need to explore scenarios to assess how it can help, rather than harm, the climate.
Amy Luers
Jonathan Koomey
Eric Horvitz
Comment22 Apr 2024
How volcanoes shaped our planet — and why we need to be ready for the next big eruption
Heather Handley
Book Review22 Apr 2024
How to freeze a memory: putting worms on ice stops them forgetting
Julian Nowogrodzki
News22 Apr 2024
Your perception of time is skewed by what you see
Lilly T
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Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex
Mezydlo et al.
Published online: April 17, 2023
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