▽Home : Nature Communications : Nature Publishing Group ●06/10 21:55 Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSCLiu et al. developed a platform to identify transcription factors (TFs) that turn stem cells into desired cell types. They discovered six key TFs that produce microglia efficiently, enhancing cell differentiation methods.Songlei LiuLi LiGeorge M. ChurchArticleOpen Access10 Jun 2025Retinoi
▽Nature Immunology ●06/10 21:53 Targeting lactylation reinforces NK cell cytotoxicity within the tumor microenvironmentLactate released by tumor cells has been shown to inhibit antitumor NK cell responses. Here the authors show a mechanism for this effect in which lactate drives lysine lactylation of NK cells. A combination treatment also limits this lactylation to prevent NK cell dysfunction, thereby restoring antitumor immuni